ACUTE GROWTH-HORMONE INJECTION REDUCED GASTROINTESTINAL AND INCREASEDHEPATIC OLEIC-ACID OXIDATION IN SWINE

Gastrointestinal. hepatic, and hindleg oxidation of H-3-labelled oleic acid and C-14-labelled glucose based on arterial-venous differences i n (H2O)-H-3 and (CO2)-C-14 were studied before and after an intravenou s injection of 24 IU of growth hormone in 10 piglets. Hepatic oleic ac id oxidation increased transiently while gastrointestinal oleic acid o xidation decreased correspondingly. maintaining a constant splanchnic oleic acid oxidation. Administration of a growth hormone led to a tran sient. parallel decrease in both hepatic and gastrointestinal glucose oxidation. We conclude that, in contrast,to the growth hormone effect on splanchnic glucose oxidation. growth hormone effect on splanchnic f at oxidation appears to be organ specific.