ADJUNCTIVE CONTROLLED TOPICAL APPLICATION OF TETRACYCLINE HCL IN THE TREATMENT OF LOCALIZED PERSISTENT OR RECURRENT PERIODONTITIS - EFFECTSON CLINICAL-PARAMETERS AND ELASTASE-ALPHA(1)-PROTEINASE INHIBITOR IN GINGIVAL CREVICULAR FLUID
Tf. Flemmig et al., ADJUNCTIVE CONTROLLED TOPICAL APPLICATION OF TETRACYCLINE HCL IN THE TREATMENT OF LOCALIZED PERSISTENT OR RECURRENT PERIODONTITIS - EFFECTSON CLINICAL-PARAMETERS AND ELASTASE-ALPHA(1)-PROTEINASE INHIBITOR IN GINGIVAL CREVICULAR FLUID, Journal of clinical periodontology, 23(10), 1996, pp. 914-921
35 patients receiving regular supportive periodontal therapy (SPT) and
showing signs of localized persistent or recurrent periodontitis were
enrolled in the study. Within 1 week after SPT, each patient had a te
tracycline HCl loaded ethylene vinyl acetate co-polymer fiber placed i
nto the periodontal pocket of 1 randomly selected tooth with persisten
t or recurrent periodontitis (test); the fiber was removed after 9.5+/
-2.0 days. A non-adjacent tooth with persistent or recurrent periodont
itis in a separate quadrant, which received no further treatment, serv
ed as a control. A total of 28 patients completed the 6-month study. C
ompared to control teeth, in test teeth at 6 months significantly (p<0
.01) lower scores were found for gingival index, pocket probing depths
, and PMN elastase-alpha(1)-proteinase inhibitor concentrations in gin
gival crevicular fluid. With the exception of plaque index scores, tes
t teeth demonstrated significant reductions from baseline to 6 months
in all parameters (p<0.05). Conversely all parameter measurements in c
ontrol teeth, except bleeding on probing, showed no significant differ
ence between baseline and 6-month values. The results suggest that the
use of controlled topical application of tetracycline HCl may improve
periodontal health and reduce the risk of disease progression in loca
lized persistent or recurrent periodontitis. Moreover, the effects of
this application appear to be sustained for at least 6 months.