ANTIPLATELET ARYLNAPHTHALIDE LIGNANS FROM JUSTICIA-PROCUMBENS

Authors
CHEN CC HSIN WC KO FN HUANG YL OU JC TENG CM
Citation
Cc. Chen et al., ANTIPLATELET ARYLNAPHTHALIDE LIGNANS FROM JUSTICIA-PROCUMBENS, Journal of natural products, 59(12), 1996, pp. 1149-1150
Citations number
15
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
12
Year of publication
1996
Pages
1149 - 1150
Database
ISI
SICI code
0163-3864(1996)59:12<1149:AALFJ>2.0.ZU;2-0
Abstract
Fractionation of the EtOH extract of Justicia procumbens, guided by an tiplatelet bioassay, led to the isolation of nine known arylnaphthalid e lignans, neojusticin A (1), justicidin B (2), justicidin A (3), taiw anin E methyl ether (4), neojusticin B (5), chinensinaphthol methyl et her (6), taiwanin E (8), chinensinaphthol (9), and diphyllin (10), and a new arylnaphthalide lignan that was characterized by spectral means as 4'-demethylchinensinaphthol methyl ether (7). Compounds 1, 2, 4, a nd 8 significantly inhibited platelet aggregation.