A 1,4-DISUBSTITUTED QUINOLIZIDINE FROM A MADAGASCAN MANTELLINE FROG (MANTELLA)

Authors
JAIN P GARRAFFO HM YEH HJC SPANDE TF DALY JW ANDRIAMAHARAVO NR ANDRIANTSIFERANA M
Citation
P. Jain et al., A 1,4-DISUBSTITUTED QUINOLIZIDINE FROM A MADAGASCAN MANTELLINE FROG (MANTELLA), Journal of natural products, 59(12), 1996, pp. 1174-1178
Citations number
18
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
12
Year of publication
1996
Pages
1174 - 1178
Database
ISI
SICI code
0163-3864(1996)59:12<1174:A1QFAM>2.0.ZU;2-R
Abstract
A major alkaloid, 217A, in skin extracts of a mantelline frog (Mantell a baroni) was isolated by HPLC and the structure defined by H-1-NMR sp ectral analysis as (1R,4S,10S)- or (1R,4R,10R)-1-methyl-4-(Z)-(1-pent- 2-en-4-ynyl) quinolizidine ii). Four other alkaloids-207I (2), 231A (3 ), 233A (4), and 235E' (5)-detected in frog skin extracts are proposed to be 1,4-disubstituted quinolizidines based on diagnostic mass and F TIR spectra.