ANTIINFLAMMATORY ACTIVITY OF COUMARINS FROM SANTOLINA-OBLONGIFOLIA

Four coumarins were isolated from the EtOAc extract of the flower-tops of Santolina oblongifolia Boiss. (Compositae). They were identified a s 7-methoxycoumarin (herniarin) (1), 6,7-dihydroxycoumarin (aesculetin ) (2), 6-methoxy-7-glucosidylcoumarin (scopolin) (3), and 6-hydroxy-7- methoxycoumarin (scopoletin) (4). This is the first report of the isol ation of aesculetin and scopolin from the genus Santolina. The isolate d coumarins showed marked activity as inhibitors of eicosanoid-release from ionophore-stimulated mouse peritoneal macrophages.