In response to changing market pressures, academic medical centers hav
e adopted a variety of coping strategies. In 1989 Ralph Snyderman beca
me chancellor for health affairs and dean of the Duke University Schoo
l of Medicine. Snyderman came to Duke after two years in senior leader
ship positions at Genentech Inc., and immediately utilized his strong
understanding of the private sector to build several innovative progra
ms at Duke. Under his aegis, Duke has worked to set up its own HMO, se
rve as a major center for clinical trials, and pioneered at times tumu
ltuous efforts to ''right-size'' its academic programs. Interviewed in
his office on the plush grounds of Duke University. Snyderman discuss
ed the future relationship of industry and academia, the economics of
medical care reimbursement, and the implications of those changes on g
raduate medical education.