INTRACAVERNOUS INJECTION OF LINSIDOMINE CHLORHYDRATE IN MONKEYS - LACK OF TOXIC EFFECT WITH LONG-TERM USE

Objective: We sought to investigate whether linsidomine chlorhydrate ( SIN1, the active metabolite of molsidomine and a nitric oxide donor) h as a toxic effect when used chronically for the treatment of impotence . Methods: We gave 50 intracavernous injections of 1.5 mg SIN1 over 25 weeks to each of 5 monkeys. Results: Four monkeys consistently respon ded with erections of sufficient rigidity and duration (mean 47.5+/-3. 3 min), and none of the five evidenced histopathologic changes of the cavernous tissue. Conclusion: SIN1 appears to be a safe option for the pharmacotherapy of erectile dysfunction.