DYNAMIC KINETIC RESOLUTION OF EPICHLOROHYDRIN VIA ENANTIOSELECTIVE CATALYTIC RING-OPENING WITH TMSN(3) - PRACTICAL SYNTHESIS OF ARYL OXAZOLIDINONE ANTIBACTERIAL AGENTS

Authors
SCHAUS SE JACOBSEN EN
Citation
Se. Schaus et En. Jacobsen, DYNAMIC KINETIC RESOLUTION OF EPICHLOROHYDRIN VIA ENANTIOSELECTIVE CATALYTIC RING-OPENING WITH TMSN(3) - PRACTICAL SYNTHESIS OF ARYL OXAZOLIDINONE ANTIBACTERIAL AGENTS, Tetrahedron letters, 37(44), 1996, pp. 7937-7940
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
44
Year of publication
1996
Pages
7937 - 7940
Database
ISI
SICI code
0040-4039(1996)37:44<7937:DKROEV>2.0.ZU;2-O
Abstract
The dynamic kinetic resolution of racemic epichlorohydrin has been ach ieved via enantioselective asymmetric ring opening with TMSN(3) cataly zed by the (salen)Cr(III)N-3 complex 1. The resulting 3-azido-1-chloro -2-trimethylsiloxypropane product was obtained in high enantiomeric pu rity and incorporated into the synthesis of U-100592, a representative from a class of highly-promising aryl oxazolidinone antibacterial age nts. Copyright (C) 1996 Elsevier Science Ltd