HETEROCYCLIC SYNTHESIS WITH ISOTHIOCYANATES - A CONVENIENT SYNTHESIS OF POLYFUNCTIONALLY SUBSTITUTED 2,3-DIHYDROTHIAZOLE, 2-(PYRAZOL-4'-YL)-THIAZOLE, 5-(THIAZOL-2'-YL)PYRIMIDINE AND THIAZOLO[3,2-A]PYRIDINE DERIVATIVES
Rm. Mohareb et al., HETEROCYCLIC SYNTHESIS WITH ISOTHIOCYANATES - A CONVENIENT SYNTHESIS OF POLYFUNCTIONALLY SUBSTITUTED 2,3-DIHYDROTHIAZOLE, 2-(PYRAZOL-4'-YL)-THIAZOLE, 5-(THIAZOL-2'-YL)PYRIMIDINE AND THIAZOLO[3,2-A]PYRIDINE DERIVATIVES, Phosphorus, sulfur and silicon and the related elements, 101(1-4), 1995, pp. 57-65
A facile convenient synthesis of the titled compounds, via cyclization
of the non-isolable 1:1 adducts 1, 9 and 13 with 4-bromo-2-phenylhydr
azono-3-oxo-butyronitrile (3), is reported. Chemical and spectroscopic
evidence of the newly synthesised compounds are described.