DIMETHYL ESTERS OF 1-AMINO-2-ARYLMETHYL CYCLOHEXYL PHOSPHONIC-ACIDS -SYNTHESIS AND NMR CHARACTERIZATION

Dimethyl esters of amino-arylmethyl phosphonic acids containing a cycl ohexyl moiety have been prepared in good yields. All compounds are whi te crystalline powders very soluble in low boiling point organic solve nts. Characterization by H-1-NMR techniques indicates that ortho subst ituents shift downfield the CH resonance, whereas ortho-carboxy groups , through hydrogen bonding with the NH group, yield a cyclic structure responsible of the dramatic downfield shift of the NH resonance.