We report on a 69 year-old patient with a leiomyoma of the seminal ves
icle who presented with dysuria and pollakiuria. The rectal examinatio
n revealed a large, hard mass in an area corresponding to the seminal
vesicle. The prostate was suspicious of malignancy, but transrectal ne
edle biopsy specimens were negative. We managed the patient by prostat
ovesiculectomy. The pathological findings and the immunohistochemical
staining pattern of smooth muscle with antibodies against beta-actin a
nd desmin confirmed the diagnosis of a leiomyoma of the left seminal v
esicle. To our knowledge, this kind of tumour is exceedingly rare, wit
h only a few cases reported in the literature.