INDUCTION OF DNAK AND GROEL HEAT-SHOCK PROTEINS BY FLUOROQUINOLONES IN ESCHERICHIA-COLI

Authors
MIZUSHIMA T MATSUO M SEKIMIZU K
Citation
T. Mizushima et al., INDUCTION OF DNAK AND GROEL HEAT-SHOCK PROTEINS BY FLUOROQUINOLONES IN ESCHERICHIA-COLI, Antimicrobial agents and chemotherapy, 41(1), 1997, pp. 193-195
Citations number
31
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
1
Year of publication
1997
Pages
193 - 195
Database
ISI
SICI code
0066-4804(1997)41:1<193:IODAGH>2.0.ZU;2-A
Abstract
Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxac in, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Esc herichia coli. The induction is transient, consistent with the kinetic s of cellular DNA relaxation. The concentrations of fluoroquinolones r equired for the induction are similar to those required for DNA relaxa tion and much higher than those required for cell death.