ANTIMICROBIAL ACTIVITY AND SPECTRUM OF LB20304, A NOVEL FLUORONAPHTHYRIDONE

Compound LB20304 is a fluoronaphthyridone carboxylic acid with a novel pyrrolidine substituent. This drug was compared with ciprofloxacin, l evofloxacin, ofloxacin, sparfloxacin, and trovafloxacin against over 8 00 pathogens, most from blood stream infections, by National Committee for Clinical Laboratory Standards reference methods, LB20304 was the most active agent against gram-positive species including strains obse rved to be resistant to other fluoroquinolones and glycopeptides. The potency of LB20304 (MIC(50), 0.03 mu g/ml) against the Enterobacteriac eae was exceeded only by that of ciprofloxacin (0.015 mu g/ml). It has limited activity against gram-negative anaerobes.