SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A CONFORMATIONALLY CONSTRAINED CHEMOTACTIC GAMMA-LACTAM FORMYL TETRAPEPTIDE

Authors
CAVICCHIONI G BREVEGLIERI A REALI E SPISANI S
Citation
G. Cavicchioni et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A CONFORMATIONALLY CONSTRAINED CHEMOTACTIC GAMMA-LACTAM FORMYL TETRAPEPTIDE, Arzneimittel-Forschung, 46(10), 1996, pp. 964-966
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
46
Issue
10
Year of publication
1996
Pages
964 - 966
Database
ISI
SICI code
0004-4172(1996)46:10<964:SABOAC>2.0.ZU;2-C
Abstract
The synthesis and biological activity on human neutrophils of for-Met- (gamma-lactam)-Leu-Phe-OMe [fM(gamma l)LP-OMe], an analogue of the che motactic fMLP-OMe, are reported. The tetrapeptide evidences chemotacti c activity as well as superoxide anion production and lysozyme release , although with lower efficacy when compared with the parent tripeptid e.