SYNTHESIS OF RING-FLUORINATED PORPHYRINS AND RECONSTITUTIONAL MYOGLOBINS WITH THEIR IRON COMPLEXES

Authors
SUZUKI A TOMIZAWA T HAYASHI T MIZUTANI T OGOSHI H
Citation
A. Suzuki et al., SYNTHESIS OF RING-FLUORINATED PORPHYRINS AND RECONSTITUTIONAL MYOGLOBINS WITH THEIR IRON COMPLEXES, Bulletin of the Chemical Society of Japan, 69(10), 1996, pp. 2923-2933
Citations number
32
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Chemical Society of Japan → ACNP
ISSN journal
00092673
Volume
69
Issue
10
Year of publication
1996
Pages
2923 - 2933
Database
ISI
SICI code
0009-2673(1996)69:10<2923:SORPAR>2.0.ZU;2-7
Abstract
The total syntheses of monofluoroporphyrin derivatives from monofluoro pyrroles and the reconstitution of synthetic heme into sperm-whale myo globin are described. The heme orientation in a cavity of the protein was determined by H-1 and F-19 NMR studies. It is noted that a fluoro substituent was found to be a useful probe for studying the heme-prote in interaction.