Introduction: Cigarette smoking poses unique, but preventable health r
isks ro women. Identification of barriers to womens' quitting is essen
tial to tailor interventions accordingly. Major depression, whether hi
storical, current, or subsyndromal, may present unique challenges to w
omen quitting smoking. Although several reviews discuss women and smok
ing in general, this review focuses exclusively on the role. of depres
sion in womens' smoking. Objectives: The goals of this review are to (
1) discuss and synthesize the current findings on the association betw
een smoking and depression in women in general, and in particular subg
roups of women (underserved, premenstrual, postpartum, menopausal), (2
) discuss physician-assisted, pharmacologic, behavioral interventions
for mood management, and (3) propose future avenues for intervention,
research, and policy. Impact of Depression: Major depression may influ
ence smoking cessation in women because (1) depression is twice as com
mon among women as men, (2) history of depression and negative affect
have been associated with smoking treatment failure, (3) quitting smok
ing is especially difficult during certain phases of the reproductive
cycle, phases that have also been associated with greater levels of dy
sphoria, and (4) subgroups of women who have a high risk of continuing
to smoke (underserved, less educated, low SES) also have a high risk
of developing depression. Conclusions: Since many women who are depres
sed (or who have developed depression during prior quit attempts) map
be less likely to seek formal cessation treatment, practitioners have
a unique opportunity to persuade their patients to quit. We discuss pa
tient-treatment matching.