ISOSTERES OF NUCLEOSIDE TRIPHOSPHATES

Authors
WEAVER R GILBERT IH MAHMOOD N BALZARINI J
Citation
R. Weaver et al., ISOSTERES OF NUCLEOSIDE TRIPHOSPHATES, Bioorganic & medicinal chemistry letters, 6(20), 1996, pp. 2405-2410
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
20
Year of publication
1996
Pages
2405 - 2410
Database
ISI
SICI code
0960-894X(1996)6:20<2405:IONT>2.0.ZU;2-2
Abstract
This paper describes the design and synthesis of lipophilic isosteres of nucleoside triphosphates as potential inhibitors of HIV reverse tra nscriptase. The isosteric replacement of the triphosphate group is a m odification of the citrate group. Copyright (C) 1996 Elsevier Science Ltd.