ADENOSINE-DEAMINASE INHIBITORS - SYNTHESIS AND BIOLOGICAL EVALUATION OF CHAIN MODIFIED ANALOGS OF (-EHNA())

Authors
PRAGNACHARYULU PVP LU PJ ABUSHANAB E
Citation
Pvp. Pragnacharyulu et al., ADENOSINE-DEAMINASE INHIBITORS - SYNTHESIS AND BIOLOGICAL EVALUATION OF CHAIN MODIFIED ANALOGS OF (-EHNA()), Bioorganic & medicinal chemistry letters, 6(20), 1996, pp. 2417-2420
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
20
Year of publication
1996
Pages
2417 - 2420
Database
ISI
SICI code
0960-894X(1996)6:20<2417:AI-SAB>2.0.ZU;2-7
Abstract
Unsaturated chain modified analogs of (+)-EHNA have been prepared and evaluated as inhibitors of adenosine deaminase. The geometry appears t o play a role in binding to the enzyme. (C) 1996 Elsevier Science Ltd.