CONCERNING THE THERMOLABILITY OF CHOLESTA-5,8-DIEN-3-BETA-OL, A STEROL THAT ACCUMULATES IN BLOOD AND TISSUES IN A HUMAN GENETIC DEVELOPMENTAL DISORDER

Authors
RUAN B PANG J WILSON WK SCHROEPFER GJ
Citation
B. Ruan et al., CONCERNING THE THERMOLABILITY OF CHOLESTA-5,8-DIEN-3-BETA-OL, A STEROL THAT ACCUMULATES IN BLOOD AND TISSUES IN A HUMAN GENETIC DEVELOPMENTAL DISORDER, Bioorganic & medicinal chemistry letters, 6(20), 1996, pp. 2421-2424
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
20
Year of publication
1996
Pages
2421 - 2424
Database
ISI
SICI code
0960-894X(1996)6:20<2421:CTTOCA>2.0.ZU;2-W
Abstract
Cholesta-5,8-dien-3 beta-ol, a sterol of current biomedical interest, undergoes facile thermal decomposition as its acetate and TMS derivati ves to the corresponding derivatives of 19-norcholesta-5,7,9-trien-3 b eta-ol. This finding may be relevant to the reported occurrence of the nortriene in blood of patients with Smith-Lemli-Opitz syndrome. Copyr ight (C) 1996 Elsevier Science Ltd.