SYNTHESIS OF A HIGHLY FUNCTIONALIZED RIGID TEMPLATE BY SOLID-PHASE AZOMETHINE YLIDE CYCLOADDITION

Authors
BICKNELL AJ HIRD NW
Citation
Aj. Bicknell et Nw. Hird, SYNTHESIS OF A HIGHLY FUNCTIONALIZED RIGID TEMPLATE BY SOLID-PHASE AZOMETHINE YLIDE CYCLOADDITION, Bioorganic & medicinal chemistry letters, 6(20), 1996, pp. 2441-2444
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
20
Year of publication
1996
Pages
2441 - 2444
Database
ISI
SICI code
0960-894X(1996)6:20<2441:SOAHFR>2.0.ZU;2-B
Abstract
A series of 1,5-diazabicyclo[3.3.0]octane-2-carboxylic acids have been synthesized in good yields and purities via cycloaddition of maleimid es to polymer supported azomethine ylides. N-Acylation of the resultin g cycloadduct enables the synthesis of diverse molecules based on a hi ghly functionalized rigid template. Copyright (C) 1996 Elsevier Scienc e Ltd.