TRIFLUOROMETHYL ALCOHOL AND KETONE INHIBITORS OF METALLO-BETA-LACTAMASES

Authors
WALTER MW FELICI A GALLENI M SOTO RP ADLINGTON RM BALDWIN JE FRERE JM GOLOLOBOV M SCHOFIELD CJ
Citation
Mw. Walter et al., TRIFLUOROMETHYL ALCOHOL AND KETONE INHIBITORS OF METALLO-BETA-LACTAMASES, Bioorganic & medicinal chemistry letters, 6(20), 1996, pp. 2455-2458
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
20
Year of publication
1996
Pages
2455 - 2458
Database
ISI
SICI code
0960-894X(1996)6:20<2455:TAAKIO>2.0.ZU;2-5
Abstract
a-Amido trifluoromethyl alcohols and ketones were synthesised via two independent routes using Ruppert's Reagent (TMS-CF3) and shown to be t he first reported synthetic inhibitors of metallo-beta-lactamases. Cop yright (C) 1996 Elsevier Science Ltd