NOVEL, SELECTIVE MECHANISM-BASED INHIBITORS OF THE HERPES PROTEASES

Authors
PINTO IL WEST A DEBOUCK CM DILELLA AG GORNIAK JG ODONNELL KC OSHANNESSY DJ PATEL A JARVEST RL
Citation
Il. Pinto et al., NOVEL, SELECTIVE MECHANISM-BASED INHIBITORS OF THE HERPES PROTEASES, Bioorganic & medicinal chemistry letters, 6(20), 1996, pp. 2467-2472
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
20
Year of publication
1996
Pages
2467 - 2472
Database
ISI
SICI code
0960-894X(1996)6:20<2467:NSMIOT>2.0.ZU;2-#
Abstract
A novel class of inhibitor of the herpes proteases acting upon the cat alytic apparatus by forming covalent complexes are described. Two new families of inhibitor, the spirocyclopropyI oxazolones and the benzyli dine N-sulphonyloxyimidazolones, have been shown to be submicromolar i nhibitors of HSV-2 and HCMV proteases which are selective relative to a panel of standard serine proteases. Copyright (C) 1996 Elsevier Scie nce Ltd