INVESTIGATION OF WATER-ADSORPTION ON KETOTIFEN FUMARATE BY INVERSE GAS-CHROMATOGRAPHY

Authors
DJORDJEVIC NM XIN ZX ASGEIRSSON K
Citation
Nm. Djordjevic et al., INVESTIGATION OF WATER-ADSORPTION ON KETOTIFEN FUMARATE BY INVERSE GAS-CHROMATOGRAPHY, Drug development and industrial pharmacy, 22(11), 1996, pp. 1153-1160
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
22
Issue
11
Year of publication
1996
Pages
1153 - 1160
Database
ISI
SICI code
0363-9045(1996)22:11<1153:IOWOKF>2.0.ZU;2-H
Abstract
A gas chromatographic technique of elution by characteristic point has been used to study water adsorption on ketotifen fumarate in the temp erature range 343-383 K. The entropy of adsorption, 50.10 kJ mol(-1), indicates a specific interaction between water and ketotifen fumarate. The isosteric heats of adsorption were viewed as a function of surfac e coverage, with the results indicating a strong adsorbate-adsorbate i nteraction.