This paper presents a non-linear modeling framework that supports mode
l development in between empirical and mechanistic modeling. A model i
s composed of a number of local models valid in different operating re
gimes. The local models are combined by smooth interpolation into a co
mplete global model. It is illustrated how different kinds of empirica
l and mechanistic knowledge and models can be combined with process da
ta within this framework. Furthermore, we describe a flexible computer
aided modeling tool that supports modeling within this framework. Sim
ple but illustrative examples from chemical engineering are used to hi
ghlight the flexibility and power of the framework. Copyright (C) 1996
Elsevier Science Ltd