The excellent biocompatibility of titanium and its alloys may result i
n osseointegration, In order to determine if this presents an obstacle
to removal of intramedullary nails, we retrospectively reviewed a ser
ies of 45 cases of isolated removal of a femoral nail. Indications for
removal were persistent pain and discomfort, request of an asymptomat
ic patient, or skeletal immaturity. Twenty-three nails were titanium,
and 22 were stainless steel. Although removal of the titanium nails ha
d a significantly longer operative time (110 vs. 84 min), analysis of
variance indicated that this was due to a greater number of crosslocki
ng screws in the titanium nails (2.2 vs. 0.6) and a tendency to set th
e titanium nails deeper in the femur. The use of the titanium material
per se did not pose a risk factor for difficulty in late removal of a
n intramedullary nail.