THE PORCINE SKELETAL-MUSCLE RYANODINE RECEPTOR GENE STRUCTURE CODING REGION 1 TO 10,614 HARBORING 71 EXONS

Authors
WEN G LEEB T REINHART B SCHMOELZL S BRENIG B
Citation
G. Wen et al., THE PORCINE SKELETAL-MUSCLE RYANODINE RECEPTOR GENE STRUCTURE CODING REGION 1 TO 10,614 HARBORING 71 EXONS, Animal genetics, 27(5), 1996, pp. 297-304
Citations number
27
Categorie Soggetti
Genetics & Heredity","Veterinary Sciences
Journal title
Animal genetics → ACNP
ISSN journal
02689146
Volume
27
Issue
5
Year of publication
1996
Pages
297 - 304
Database
ISI
SICI code
0268-9146(1996)27:5<297:TPSRRG>2.0.ZU;2-U
Abstract
The skeletal muscle ryanodine receptor (RYR1) belongs to a family of c alcium release channels that are expressed in different tissues, The R YR1 gene is one of the largest genes characterized, so far, containing a 15253 nucleotide ORF in swine. To study the genomic organization of the porcine skeletal muscle ryanodine receptor gene we have isolated seven genomic fragments spanning 72 . 7 kb of chromosomal DNA of chrom osome 6q12, This region harbours exons 1 to 71 coding for 3538 amino a cids (69 . 6%) of the ryanodine receptor 1.