Gf. Wiegertjes et al., CHARACTERIZATION OF ISOGENIC CARP (CYPRINUS-CARPIO L.) LINES WITH A GENETICALLY-DETERMINED HIGH OR LOW ANTIBODY-PRODUCTION, Animal genetics, 27(5), 1996, pp. 313-319
Antibody production to dinitrophenyl-keyhole limpet haemocyanin (DNP-K
LH) served as the immune parameter to divergently select carp (Cyprinu
s carpio L.) to produce high- and low-responder F-1 hybrid lines, Anti
body production to trinitrophenyl-lipopolysaccharide (TNP-LPS) and to
DNP-KLH were similar in magnitude. By contrast, some high-responder li
nes were low responders to DNP-human serum albumin, and vice versa. Lo
w-responder carp were relatively susceptible to infection with the par
asite Trypanoplasma borreli. This suggested that at least one gene wit
h a major influence on resistance differed between the two homozygous
parents (69, 85) used to generate the high- and low-responder homozygo
us families, respectively. The isogenic lines showed no within-line va
riation in DNA fingerprints, but differed with respect to their MhcCyc
a-DAB genes.