THE PORCINE TTR LOCUS MAPS TO CHROMOSOME 6Q

The sequence of a cDNA clone encoding porcine transthyretin (prealbumi n) was used to develop polymorphic markers for the TTR locus. The sing le-strand conformation polymorphism (SSCP) detected is caused by a sil ent A/T mutation in the penultimate coding codon and can also be revea led as a SacI restriction fragment length polymorphism (RFLP). The TTR locus was mapped to chromosome 6q by segregation and linkage analysis with these polymorphisms. This assignment confirms the predictions of homology between human chromosome 18 and pig chromosome 6q2 . 5-q2 . 6.