R. Cohen et al., IN-VITRO SUSCEPTIBILITY OF STREPTOCOCCUS- PYOGENES STRAINS RECENTLY ISOLATED FROM PHARYNGOTONSILLITIS IN FRANCE, Medecine et maladies infectieuses, 26(8-9), 1996, pp. 765-769
Between November 1995 and May 1996, 173 French general practitioners c
onducted an epidemiologic survey to evaluate the susceptibility of Str
eptococcus pyogenes isolated from acute pharyngotonsillitis. 2800 adul
ts and children over 4 years of age were enrolled. Among them, 393 had
positive rapid strep tests (Testpack plus Strep A(R), Abbott), 375 un
derwent bacteriological sample for culture. 324 Streptococcus pyogenes
were isolated and the predictive positive value of the test was 86.4
%. The minimum inhibitory concentrations (MIC) of several oral antibio
tics were determined by the agar dilution method. All 324 strains were
susceptible to penicillin, ampicillin, cefaclor (concentration of ant
ibiotic required to inhibit 90 % of isolates, respectively, 0.016, 0.0
32, 0.5 mu gr/ml). For erythromycin, 94.5 % (306/324) of tested strain
s were susceptible, 18 had MIC of 2 mu gr/ml or greater (MIC between 2
and 4 mu gr/ml for 10 isolates and MIC greater than or equal to 8 mu
gr/ml for 8 isolates).