P. Wlaz et Z. Rolinski, XYLAZINE IMPAIRS THE ANTICONVULSANT ACTIVITY OF CONVENTIONAL ANTIEPILEPTIC DRUGS IN MICE, Journal of veterinary medicine. Series A, 43(8), 1996, pp. 495-500
In this study the influence of xylazine upon the threshold of electric
ally-induced convulsions and the anticonvulsant action of diazepam, ph
enobarbital and phenytoin was studied in mice. hll drugs were given as
solutions intraperitoneally (i.p.). Xylazine did not alter seizure th
reshold at any of the doses tested (range 0-6 mg/kg i.p.). However, wh
en combined with seizure-increasing doses of phenobarbital and phenyto
in, xylazine at a dose of 2 mg/kg significantly (P <0.05) reduced the
ability of these anticonvulsants to increase seizure threshold. Xylazi
ne also reduced the anticonvulsant effect of diazepam, though insignif
icantly. Our data indicate that xylazine should be contraindicated in
animals on the anticonvulsant medication.