XYLAZINE IMPAIRS THE ANTICONVULSANT ACTIVITY OF CONVENTIONAL ANTIEPILEPTIC DRUGS IN MICE

Authors
Citation
P. Wlaz et Z. Rolinski, XYLAZINE IMPAIRS THE ANTICONVULSANT ACTIVITY OF CONVENTIONAL ANTIEPILEPTIC DRUGS IN MICE, Journal of veterinary medicine. Series A, 43(8), 1996, pp. 495-500
Citations number
17
Categorie Soggetti
Veterinary Sciences
ISSN journal
0931184X
Volume
43
Issue
8
Year of publication
1996
Pages
495 - 500
Database
ISI
SICI code
0931-184X(1996)43:8<495:XITAAO>2.0.ZU;2-4
Abstract
In this study the influence of xylazine upon the threshold of electric ally-induced convulsions and the anticonvulsant action of diazepam, ph enobarbital and phenytoin was studied in mice. hll drugs were given as solutions intraperitoneally (i.p.). Xylazine did not alter seizure th reshold at any of the doses tested (range 0-6 mg/kg i.p.). However, wh en combined with seizure-increasing doses of phenobarbital and phenyto in, xylazine at a dose of 2 mg/kg significantly (P <0.05) reduced the ability of these anticonvulsants to increase seizure threshold. Xylazi ne also reduced the anticonvulsant effect of diazepam, though insignif icantly. Our data indicate that xylazine should be contraindicated in animals on the anticonvulsant medication.