INFLUENCE OF ORGANIC MODIFIER AND TEMPERATURE ON THE ENANTIOMERIC SEPARATION OF GAMMA-LACTAMS BY HPLC

Authors
FICARRA R CALABRO ML TOMMMASINI S COSTANTINO D CARULLI M MELARDI S DIBELLA MR CASUSCELLI F ROMEO R FICARRA P
Citation
R. Ficarra et al., INFLUENCE OF ORGANIC MODIFIER AND TEMPERATURE ON THE ENANTIOMERIC SEPARATION OF GAMMA-LACTAMS BY HPLC, Chromatographia, 43(7-8), 1996, pp. 365-368
Citations number
9
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Chromatographia → ACNP
ISSN journal
00095893
Volume
43
Issue
7-8
Year of publication
1996
Pages
365 - 368
Database
ISI
SICI code
0009-5893(1996)43:7-8<365:IOOMAT>2.0.ZU;2-7
Abstract
A high-performance liquid chromatographic method is reported for the r esolution of the enantiomers of a series of fused gamma-lactams (2,7-d iaza-3-oxo[3.3.0]octan-6-ones) with probable anti-HIV and anticancer a ctivity. Resolution was achieved on a Chiralcel(R) OD column, cellulos e tris-(3,5-dimethylphenyl carbamate) adsorbed on macroporous silica g el; mixtures of n-hexane and isopropyl alcohol in different proportion s were used as the mobile phase. The analysis was studied at different temperatures.