RECOGNITION OF AMINOGLYCOSIDE ANTIBIOTICS BY ENTEROCOCCAL-STAPHYLOCOCCAL AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE TYPE IIIA - ROLE OF SUBSTRATEAMINO-GROUPS

Authors
MCKAY GA ROESTAMADJI J MOBASHERY S WRIGHT GD
Citation
Ga. Mckay et al., RECOGNITION OF AMINOGLYCOSIDE ANTIBIOTICS BY ENTEROCOCCAL-STAPHYLOCOCCAL AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE TYPE IIIA - ROLE OF SUBSTRATEAMINO-GROUPS, Antimicrobial agents and chemotherapy, 40(11), 1996, pp. 2648-2650
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
11
Year of publication
1996
Pages
2648 - 2650
Database
ISI
SICI code
0066-4804(1996)40:11<2648:ROAABE>2.0.ZU;2-G
Abstract
The interactions of the aminoglycoside 3'-phosphotransferase IIIa with aminoglycoside antibiotics lacking specific amino groups were examine d by steady-state kinetic analyses. The results demonstrate that an am ino group on C-1 and either an amino or a hydroxyl group at the 2' and 6' positions are important for detoxification of aminoglycosides by t his enzyme.