COMPARATIVE ANTIMYCOBACTERIAL ACTIVITIES OF RIFAMPIN, RIFAPENTINE, AND KRM-1648 AGAINST A COLLECTION OF RIFAMPIN-RESISTANT MYCOBACTERIUM-TUBERCULOSIS ISOLATES WITH KNOWN RPOB MUTATIONS

Authors
MOGHAZEH SL PAN X ARAIN T STOVER CK MUSSER JM KREISWIRTH BN
Citation
Sl. Moghazeh et al., COMPARATIVE ANTIMYCOBACTERIAL ACTIVITIES OF RIFAMPIN, RIFAPENTINE, AND KRM-1648 AGAINST A COLLECTION OF RIFAMPIN-RESISTANT MYCOBACTERIUM-TUBERCULOSIS ISOLATES WITH KNOWN RPOB MUTATIONS, Antimicrobial agents and chemotherapy, 40(11), 1996, pp. 2655-2657
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
11
Year of publication
1996
Pages
2655 - 2657
Database
ISI
SICI code
0066-4804(1996)40:11<2655:CAAORR>2.0.ZU;2-D
Abstract
A collection of 24 rifampin-resistant clinical isolates of Mycobacteri um tuberculosis with characterized RNA polymerase beta-subunit (rpoB) gene mutations was tested against the antimycobacterial agents rifampi n, rifapentine, and KRM-1648 to correlate levels of resistance with sp ecific rpoB genotypes. The results indicate that KRM-1648 is more acti ve in vitro than rifampin and rifapentine, and its ability to overcome rifampin resistance in strains with four different genetic alteration s may prove to be useful in understanding structure-function relations hips.