COMPARATIVE ACTIVITIES OF LY-333328, A NEW GLYCOPEPTIDE, AGAINST PENICILLIN-SUSCEPTIBLE AND PENICILLIN-RESISTANT PNEUMOCOCCI

Authors
FASOLA E SPANGLER SK EDNIE LM JACOBS MR BAJAKSOUZIAN S APPELBAUM PC
Citation
E. Fasola et al., COMPARATIVE ACTIVITIES OF LY-333328, A NEW GLYCOPEPTIDE, AGAINST PENICILLIN-SUSCEPTIBLE AND PENICILLIN-RESISTANT PNEUMOCOCCI, Antimicrobial agents and chemotherapy, 40(11), 1996, pp. 2661-2663
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
11
Year of publication
1996
Pages
2661 - 2663
Database
ISI
SICI code
0066-4804(1996)40:11<2661:CAOLAN>2.0.ZU;2-1
Abstract
Microdilution MIC testing was used to test the susceptibility of 202 p neumococci to LY 333328 and six other agents. LY 333328 was the most a ctive glycopeptide (MIG at which 90% of the pneumococci were inhibited [MIC(90)], 0.008 mu g/ml), followed by teicoplanin (MIC(90), 0.06 mu g/ml) and vancomycin (MIC(90), 0.5 mu g/ml). Rifampin resistance was s een in some penicillin-resistant strains. The MICs of imipenem and cef triaxone rose with those of penicillin. Time-kill testing confirmed th e excellent antipneumococcal activity of LY 333328.