SYNERGISTIC EFFECT OF ETHYL-6-O-DECANOYL GLUCOSIDE AND CHLORHEXIDINE IN CONTACT-LENS DISINFECTION

Authors
LEHTONEN OPJ VAAHTORANTALEHTONEN H LEIVO P MAKI M
Citation
Opj. Lehtonen et al., SYNERGISTIC EFFECT OF ETHYL-6-O-DECANOYL GLUCOSIDE AND CHLORHEXIDINE IN CONTACT-LENS DISINFECTION, APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, 104(7-8), 1996, pp. 603-606
Citations number
9
Categorie Soggetti
Pathology,Microbiology,Immunology
Journal title
APMIS. Acta pathologica, microbiologica et immunologica Scandinavica → ACNP
ISSN journal
09034641
Volume
104
Issue
7-8
Year of publication
1996
Pages
603 - 606
Database
ISI
SICI code
0903-4641(1996)104:7-8<603:SEOEGA>2.0.ZU;2-W
Abstract
Contact lenses with adherent Serratia marcescens and Pseudomonas aerug inosa could not be sterilised either with polyaminopropyl biguanide or with chlorhexidine (CHX) commercial solutions meant for contact lens disinfection, even after treatment lasting 12 h. Ethyl-6-O-decanoyl gl ucoside (EDG) with chlorhexidine enhanced the killing significantly. T he same was also found to be the case for dispersed cells of P. aerugi nosa on cellulose acetate filters. EDG enhances the bactericidal effec t of 0.00025 CHX by a mechanism not solely due to detergent action and is a potential adjunct to CHX in clinical applications.