IDENTIFICATION AND MOLECULAR-CLONING OF A 67-KILODALTON PROTEIN IN SCHISTOSOMA-JAPONICUM HOMOLOGOUS TO A FAMILY OF ACTIN-BINDING PROTEINS

Authors
KURTIS JD RAMIREZ BL WIEST PM DONG KL ELMEANAWY A PETZKE MM JOHNSON JH EDMISON J MAIER RA OLDS GR
Citation
Jd. Kurtis et al., IDENTIFICATION AND MOLECULAR-CLONING OF A 67-KILODALTON PROTEIN IN SCHISTOSOMA-JAPONICUM HOMOLOGOUS TO A FAMILY OF ACTIN-BINDING PROTEINS, Infection and immunity, 65(1), 1997, pp. 344-347
Citations number
27
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
1
Year of publication
1997
Pages
344 - 347
Database
ISI
SICI code
0019-9567(1997)65:1<344:IAMOA6>2.0.ZU;2-5
Abstract
A monoclonal antibody to Schistosoma japonicum which conferred signifi cant protection against cercarial challenge in mice was produced. The predicted translation product of the cDNA corresponding to the antigen recognized by this antibody was homologous to a newly identified fami ly of actin-binding proteins. The expressed protein bound polymerized actin and was recognized by serum from patients infected with S. japon icum.