3'-DEOXY-2',3'-DIFLUOROTHYMIDINE, A NUCLEOSIDE ANALOG

Authors
DAS AK MUKHOPADHYAY A DAS N MAZUMDAR SK BERTOLASI V VANAERSCHOT A
Citation
Ak. Das et al., 3'-DEOXY-2',3'-DIFLUOROTHYMIDINE, A NUCLEOSIDE ANALOG, Acta crystallographica. Section C, Crystal structure communications, 52, 1996, pp. 2615-2616
Citations number
11
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
52
Year of publication
1996
Part
10
Pages
2615 - 2616
Database
ISI
SICI code
0108-2701(1996)52:<2615:3ANA>2.0.ZU;2-T
Abstract
The title compound, 1-(2,3-dideoxy-2, 3-difluoro-beta-D-ribopentofuran osyl)thymine, C10H12F2N2O4, consists of an almost planar heterocyclic base moiety oriented anti with respect to a puckered sugar moiety. The sugar pucker is T-2(3) and the N-glycosidic torsion angle is -119.6(2 )degrees. The conformation of the O5' atom is +sc and the molecules ar e held together by a network of N-H ... O and O-H ... O hydrogen bonds .