CONFORMATIONAL EQUILIBRIA IN QUINOLIZIDINE ALKALOIDS

Authors
WYSOCKA W BRUKWICKI T
Citation
W. Wysocka et T. Brukwicki, CONFORMATIONAL EQUILIBRIA IN QUINOLIZIDINE ALKALOIDS, Journal of molecular structure, 385(1), 1996, pp. 23-33
Citations number
50
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular structure → ACNP
ISSN journal
00222860
Volume
385
Issue
1
Year of publication
1996
Pages
23 - 33
Database
ISI
SICI code
0022-2860(1996)385:1<23:CEIQA>2.0.ZU;2-Z
Abstract
A method involving H-1 and C-13 NMR spectroscopy was used for quantita tive determination of conformational equilibria in 12 bis-quinolizidin e alkaloids and their two salts. In view of the three criteria, i.e. C -13 chemical shifts for C12 and C14 as well as the coupling constant H 7-H17 beta, the results were consistent. The coupling constant H7-H17 beta was valid also for three-ring quinolizidine-piperidine alkaloids. Factors influencing the equilibria were discussed.