Ja. Sorkin et al., OPTIC-NERVE HYPOPLASIA - ABSENCE OF POSTERIOR PITUITARY BRIGHT SIGNALON MAGNETIC-RESONANCE-IMAGING CORRELATES WITH DIABETES-INSIPIDUS, American journal of ophthalmology, 122(5), 1996, pp. 717-723
PURPOSE: Magnetic resonance imaging has been used to examine children
with optic nerve hypoplasia for pituitary abnormalities who may be at
risk for anterior pituitary hormonal deficiencies. We correlated the s
ellar and optic pathway anatomic findings on magnetic resonance imagin
g in children with optic nerve hypoplasia with findings from their end
ocrinologic and ophthalmologic examinations to determine whether magne
tic resonance imaging findings predict anterior and posterior pituitar
y dysfunction. METHODS: A retrospective review identified five childre
n with optic nerve hypoplasia and endocrinopathy who also underwent hi
gh resolution volumetric magnetic resonance imaging. RESULTS: All chil
dren had severe bilateral optic nerve hypoplasia and anterior pituitar
y hormone deficiencies. Three children had no recognizable intrasellar
or ectopic posterior pituitary bright spot on magnetic resonance imag
ing; all had clinical evidence of diabetes insipidus. Two patients wit
h a recognizable but ectopic posterior pituitary did not have diabetes
insipidus. CONCLUSION: Children with optic nerve hypoplasia and no re
cognizable posterior lobe of the pituitary gland on magnetic resonance
imaging are at risk for both anterior and posterior pituitary dysfunc
tion, whereas those with a posterior lobe on magnetic resonance imagin
g appear to have intact posterior pituitary function.