THE EFFECT OF CULTURE CONDITIONS ON THE PRODUCTION OF ERYTHROMYCIN BYSACCHAROPOLYSPORA-ERYTHRAEA IN BATCH CULTURE

Authors
HEYDARIAN SM LILLY MD ISON AP
Citation
Sm. Heydarian et al., THE EFFECT OF CULTURE CONDITIONS ON THE PRODUCTION OF ERYTHROMYCIN BYSACCHAROPOLYSPORA-ERYTHRAEA IN BATCH CULTURE, Biotechnology letters, 18(10), 1996, pp. 1181-1186
Citations number
12
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
18
Issue
10
Year of publication
1996
Pages
1181 - 1186
Database
ISI
SICI code
0141-5492(1996)18:10<1181:TEOCCO>2.0.ZU;2-R
Abstract
Saccharopolyspora erythraea growth is inhibited when grown at a low co nstant dissolved oxygen tension (DOT) of 10% air saturation. However, the specific erythromycin production is virtually identical to that of a culture where the DOT did not fall below 65%. In addition, at const ant DOT (10%) a stirrer speed of 750 rpm in a 7 litre causes mechanica l damage to the mycelia in comparison with result at 500 rpm.