SURGICAL RESECTION OF PRIMARY HEPATOCELLULAR-CARCINOMA EXTENDING TO ADJACENT ORGAN(S)

Citation
Wy. Tung et al., SURGICAL RESECTION OF PRIMARY HEPATOCELLULAR-CARCINOMA EXTENDING TO ADJACENT ORGAN(S), European journal of surgical oncology, 22(5), 1996, pp. 516-520
Citations number
26
Categorie Soggetti
Surgery,Oncology
ISSN journal
07487983
Volume
22
Issue
5
Year of publication
1996
Pages
516 - 520
Database
ISI
SICI code
0748-7983(1996)22:5<516:SROPHE>2.0.ZU;2-H
Abstract
Primary hepatocellular carcinoma (HCC) extending to the adjacent organ (s) is sometimes encountered in patients with large, peripherally loca ted tumours, Over a l-year period, a total of 151 patients received cu rative resection of HCC at the Surgical Department of Veterans General Hospital-Taipei, Taiwan, Of these patients, 21 underwent hepatic rese ction combined with en-bloc resection of the adjacent organ(s) because tumour extension was found during operation, Subsequent histological examination of the resected specimens found evidence of HCC invasion i nto the resected adjacent organ(s) in only nine patients (group I), an d the remaining 12 patients showed no evidence of extrahepatic HCC inv asion (group II), Twenty-seven HCC patients with clinico-pathologicall y matched tumours but without extrahepatic extension mere selected as controls (group III), One patient in group I died of hepatic failure a fter the operation, The morbidity rate was 48% in group I and group II patients, and 30% in group III patients, The difference was not stati stically significant, On evaluating the clinico-pathological factors, including DNA ploidy status of the tumours, there mere no significant differences between tumours with and without extrahepatic invasion, Pa tients with locally invasive HCC (group I) had disease-free and overal l survival rates comparable with those of the patients without local t umour invasion (group II and III), We conclude that HCC with invasion to the adjacent organ(s) does not seem to be directly related to the ' aggressiveness' of the tumour, and extrahepatic infiltration of the tu mour does not preclude a chance of cure, Our results underscore the ne ed for en-bloc resection as treatment of choice for these patients.