ISOLATION AND STRUCTURE OF LEUKOTRIENE-A(4) HYDROLASE INHIBITOR - 8(S)-AMINO-2(R)-METHYL-7-OXONONANOIC ACID PRODUCED BY STREPTOMYCES-DIASTATICUS

Authors
PARNAS BL DURLEY RC RHODEN EE KILPATRICK BF MAKKAR N THOMAS KE SMITH WG CORLEY DG
Citation
Bl. Parnas et al., ISOLATION AND STRUCTURE OF LEUKOTRIENE-A(4) HYDROLASE INHIBITOR - 8(S)-AMINO-2(R)-METHYL-7-OXONONANOIC ACID PRODUCED BY STREPTOMYCES-DIASTATICUS, Journal of natural products, 59(10), 1996, pp. 962-964
Citations number
12
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
10
Year of publication
1996
Pages
962 - 964
Database
ISI
SICI code
0163-3864(1996)59:10<962:IASOLH>2.0.ZU;2-2
Abstract
The novel amino acid 8(S)-amino-2(R)-methyl-7-oxononanoic acid (1) was isolated from the soil-borne microorganism Streptomyces diastaticus d uring our screening for inhibitors of leukotriene-A(4) hydrolase (LTA( 4)H), a requisite enzyme in the biosynthesis of the potent inflammator y mediator leukotriene-B-4 (LTB(4)). The structure of 1 was determined by detailed spectroscopic analyses and is related to 7-keto-8-aminope largonic acid (2), a biosynthetic precursor of biotin. The relative po tency of 1 (LTA(4)H IC50 = 0.6 mu M) warranted further biological stud ies.