The changes in ipsilateral sympathetic tone in response to axillary pr
essure are well known. However, the response of the nasal mucosa is le
ss well documented. We have attempted to demonstrate this response in
normal individuals. Ten individuals with no history of nasal disease o
r allergy were studied. All subjects were exposed to sustained pressur
e, using a crutch, for a period of 5 min. Nasal cross-sectional area w
as measured on both sides of the nose using an acoustic rhinometer alo
ng with pulse and blood pressure. The individuals were then rested for
at least 30 min and the test repeated with pressure applied to the op
posite side. Statistical analysis was performed by non-parametric meth
ods. There was a significant fall in nasal cross-sectional area on the
side of pressure (median change = 0.09 cm(2), P < 0.01) while cross-s
ectional area in the contralateral nasal passage increased (median cha
nge = 0.35 cm(2), P = 0.01). There were no significant differences bet
ween these results and those obtained by axillary pressure on the oppo
site side. Pulse and diastolic blood pressure rose with axillary press
ure while systolic blood pressure remained unaltered. There was no dif
ference in the laterality in the blood pressure response. The results
indicate that axillary pressure produces nasal congestion and both aff
erent and efferent arms of this reflex are side-specific.