La. Morrow et al., DIFFERENTIAL ASSOCIATIONS OF P300 AMPLITUDE AND LATENCY WITH COGNITIVE AND PSYCHIATRIC FUNCTION IN SOLVENT-EXPOSED ADULTS, The Journal of neuropsychiatry and clinical neurosciences, 8(4), 1996, pp. 446-449
Cognitive and mood changes are central components of solvent encephalo
pathy. This study examined event-related potentials in relation to neu
ropsychological and psychiatric function in solvent-exposed adults. Re
sults revealed that longer P300 latency was associated with poorer cog
nitive test scores, whereas reduced P300 amplitude was related to incr
eased psychiatric symptomatology. The findings suggest that the cognit
ive deficits and the psychiatric disturbance following solvent exposur
e may have different neurophysiological bases.