A variety of methods have been proposed for analyzing and summarizing
data from clinical trials of pharmaceutical agents, Methods directed a
t evaluating the speed of activity of an agent are an important compon
ent of such analyses, We review several parameters that are useful for
comparing speed of effectiveness and demonstrate their utility, both
with didactic examples and with real data. The ''survival function'' i
s well suited to evaluating speed of cure, particularly when there is
a fraction of the population that does not respond to a particular tre
atment, Some conditional parameters, such as the survival function amo
ng those who are curable, are shown to be inappropriate for the compar
ison of speeds of cure because they summarize speed of activity in dif
ferent, and therefore noncomparable, populations, Comparisons based on
these conditional survival curves are inappropriate and can lead to t
he wrong interpretation even when one treatment completely dominates a
nother with respect to speed and efficacy, Methods appropriate for det
ermining an optimal sequence of treatments are briefly reviewed, Examp
les from the published literature, as well as data from a recent study
of venlafaxine, are used to demonstrate both appropriate and flawed i
nterpretations of clinical trial data.