Ss. Falkenberry et al., SYNCHRONOUS ENDOMETRIOID TUMORS OF THE OVARY AND ENDOMETRIUM - A CLINICOPATHOLOGIC STUDY OF 22 CASES, Journal of reproductive medicine, 41(10), 1996, pp. 713-718
OBJECTIVE: To analyze a group of 22 patients with synchronous endometr
ioid tumors of the ovary and endometrium. STUDY DESIGN: A retrospectiv
e chart review was undertaken and information collected or 2 patient a
ge, parity, tumor grade and stage, presence of coexisting endometriosi
s and survival. Flow cytometry was determined from archival samples of
the endometrial and ovarian tumors. RESULTS: The mean age at diagnosi
s was 52.8 years (range 36-71); mean parity was 1.05. With regard to t
he endometrial component, 68.2% were grade 1, 63.6% were stage I and,
by flow cytometry, 62.5% were aneuploid. With regard to the ovarian le
sions, 68.2% were grade 1, 68.2% were stage I, and 72.4% were aneuplo
id by flow cytometry. Twelve (54.5%) of 22 patients had pathologic evi
dence of coexisting endometriosis. Overall, three-year survival was 75
%. All II patients with stage I disease at both sites were alive, with
out disease, at a mean follow-up of 34.9 months. CONCLUSION: Patients
with synchronous endometrioid tumors of the endometrium and ovary are
generally younger than reported for either endometrial adenocarcinomas
or ovarian epithelial adenocarcinomas. They tend to be low grade and
early stage and are frequently associated with endometriosis. Our data
suggest that the survival of patients with synchronous primaries corr
elates with the stage of the individual tumors and that a second, sync
hronous primary does not adversely affect prognosis.