SYNCHRONOUS ENDOMETRIOID TUMORS OF THE OVARY AND ENDOMETRIUM - A CLINICOPATHOLOGIC STUDY OF 22 CASES

OBJECTIVE: To analyze a group of 22 patients with synchronous endometr ioid tumors of the ovary and endometrium. STUDY DESIGN: A retrospectiv e chart review was undertaken and information collected or 2 patient a ge, parity, tumor grade and stage, presence of coexisting endometriosi s and survival. Flow cytometry was determined from archival samples of the endometrial and ovarian tumors. RESULTS: The mean age at diagnosi s was 52.8 years (range 36-71); mean parity was 1.05. With regard to t he endometrial component, 68.2% were grade 1, 63.6% were stage I and, by flow cytometry, 62.5% were aneuploid. With regard to the ovarian le sions, 68.2% were grade 1, 68.2% were stage I, and 72.4% were aneuplo id by flow cytometry. Twelve (54.5%) of 22 patients had pathologic evi dence of coexisting endometriosis. Overall, three-year survival was 75 %. All II patients with stage I disease at both sites were alive, with out disease, at a mean follow-up of 34.9 months. CONCLUSION: Patients with synchronous endometrioid tumors of the endometrium and ovary are generally younger than reported for either endometrial adenocarcinomas or ovarian epithelial adenocarcinomas. They tend to be low grade and early stage and are frequently associated with endometriosis. Our data suggest that the survival of patients with synchronous primaries corr elates with the stage of the individual tumors and that a second, sync hronous primary does not adversely affect prognosis.