DIPHENCYPRONE IN THE MANAGEMENT OF REFRACTORY PALMOPLANTAR AND PERIUNGUAL WARTS - AN OPEN STUDY

Background: Induction of delayed-type hypersensitivity has recently be en introduced for resistant viral warts. The method is not painful and less destructive than most other modalities. Objective: We assessed t he efficacy of topical diphencyprone (diphenylcyclopropenone) treatmen t for recalcitrant warts. Methods: From September 1988 to June 1995, 1 34 patients with periungual and/or palmoplantar warts were entered int o the study. Eight weekly applications were delivered. Results: The sc heduled treatment course and follow-up were completed by 111 patients. There were 49 complete and Is partial remissions. The rate of positiv e responders (60%) compares with the results published by other author s. Conclusion: Diphencyprone is an effective treatment for resistant w arts, especially in palmoplantar and periungual locations.