Concerns have been raised frequently about caffeine's potential for in
creasing blood pressure (BP) and posing a risk for cardiovascular dise
ase. This review surveys research concerning the effects of caffeine o
n BP and heart rate (HR). Tolerance to caffeine, family history of hyp
ertension, borderline hypertension; and hypertension are also examined
as potential moderators. Results from epidemiological studies are inc
onsistent. Experimental laboratory studies have generally found that c
af feine produces acute rises in systolic and diastolic BP that are ad
ditive to any stress-induced increases. Synergistic effects which migh
t pose a more serious risk are rarely found. Heart rate data are less
consistent, possibly due to the different ways HR is measured. Toleran
ce to the cardiovascular effects of caffeine has reliably been reporte
d; however, overnight abstinence may be sufficient to negate tolerance
effects to most levels of caffeine ingestion in typical caffeine user
s. Though caffeine drinkers may exhibit acute increases in BP, the lon
g-term effects appear to be minimal. However, persons at risk for hype
rtension may be more vulnerable to the BP effects of caffeine.