Many commonly prescribed medications and substances of abuse can have
significant effects on sleep and wakefulness. Chronic use or abuse of
certain drugs may lead to the development of substance-related sleep d
isorders. Primary sleep disorders, such as apnea, periodic movement di
sorders, and parasomnias, may be exacerbated by various drugs. This ar
ticle summarizes the effects of widely used medications and recreation
al drugs on sleep.