Two children with primary amoebic meningoencephalitis secondary to Nae
gleria fowleri are reported. Both children died, and the causative age
nt was identified at autopsy, Presentation and outcome conformed to th
e usual course of primary amoebic meningoemcephalitis and reaffirm the
gravity and rapid progression of this infection, The epidemiology, mi
crobiology, diagnostic considerations, and treatment are discussed. Pr
imary amoebic meningoencephalitis should be considered in the differen
tial diagnosis of children with meningitis or encephalitis. (C) 1996 b
y Elsevier Science Inc. All rights reserved.